Organonitrogen Compounds
Medchemexpress LLC H3B-6545 | 2052130-80-8 | 99.4% | 567.58 | 50 MG
H3B-6545 is an oral, selective estrogen receptor covalent antagonist (SERCA) for the research of metastatic ER-positive, HER2-negative breast cancer. It is for research use only and not sold to patients.
- Oral, selective estrogen receptor covalent antagonist (SERCA).
- Designed for research into metastatic ER-positive, HER2-negative breast cancer.
- Potently antagonizes wild-type and mutant ERα in biochemical and cell-based assays.
- Inactivates wild-type and mutant ERα by targeting C530.
- Inhibits ERαWT activity and suppresses proliferation of ERαWT-positive breast cancer cell lines.
- Demonstrates superior efficacy to fulvestrant and tamoxifen in xenograft and patient-derived xenograft models.
- Well tolerated across a broad dose range in rats and monkeys.
Medchemexpress LLC CCR4-351 | 2174938-70-4 | MFCD32701932 | 99.0% | C24H27Cl2N7O | 10MG
CCR4-351 is an orally active, potent, and selective chemokine receptor 4 (CCR4) antagonist for research use. It features a novel piperidinyl-azetidine motif and exhibits low-nanomolar activity in functional assays (reported IC50 ≈ 22 nM in calcium flux and ≈ 50 nM in CTX). The compound has shown antitumor activity in preclinical studies and is supplied at high purity for experimental applications.
- Potent CCR4 antagonist with low-nanomolar activity.
- Selective activity in CCR4 functional assays.
- Demonstrated antitumor activity in preclinical models.
- Suitable for in vitro and in vivo CCR4 pathway research.
- High purity (≈98.95%) for reliable experimental results.
eMolecules 594-14-9 | Guanidine sulfate | Combi-Blocks, Inc. | MFCD00013115 | 216.220 | C2H12N6O4S | 98.000 | NC(N)=N.NC(N)=N.OS(O)(=O)=O | 25g | 603137217
Guanidine sulfate | Combi-Blocks, Inc. | 594-14-9 | MFCD00013115 | 216.220 | C2H12N6O4S | 98.000 | NC(N)=N.NC(N)=N.OS(O)(=O)=O | 25g | 603137217
Medchemexpress LLC Clonidine (hydrochloride) | 4205-91-8 | 99.9% | 1 G
Clonidine hydrochloride is an agonist of α2-adrenoceptor and a potent antihypertensive agent. It has been studied for its various biological activities.
- Induces CGRP (α and β) mRNA expression in endothelial cells
- Increases NO levels in endothelial cells
- Decreases rat body temperature
- Suppresses dopamine efflux in the prefrontal cortex
- Reduces blood pressure
- Enhances RVLM pERK1/2
Sigma Aldrich Fine Chemicals Biosciences Creatine | 57-00-1 | MFCD00004282 | 50g
Creatine | Mol Wt: 131.13 | 57-00-1 | MFCD00004282 | 50g
Medchemexpress LLC Bnc375 | 1557240-80-8 | 99.6% | 394.92 g/mol | C19H23ClN2O3S | 5 MG
BNC375 is a small-molecule, orally available type I positive allosteric modulator of the α7 nicotinic acetylcholine receptor (α7 nAChR). It demonstrates an EC50 of about 1.9 μM and exhibits CNS drug-like properties, supplied as a high-purity research chemical for in vitro and in vivo pharmacology studies.
- Potent, selective type I positive allosteric modulator of α7 nAChR.
- EC50 approximately 1.9 μM in functional assays.
- High purity suitable for in vitro and in vivo studies.
- Soluble in DMSO; recommended in vivo formulations provided.
- Available in milligram-scale quantities for research use.
- Storage recommendations provided to maintain stability.
Medchemexpress LLC Mitraphylline | 509-80-8 | 10 MG
Mitraphylline is the major pentacyclic oxindolic alkaloid found in Uncaria tomentosa. It inhibits lipopolysaccharide-mediated activation of primary human neutrophils and exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can also inhibit interleukin release in vivo.
- Purity: 99.30%
- Appearance: solid, white to off-white
- Solubility (in vitro): 6.76 mg/mL in DMSO (18.35 mM); requires ultrasonic
- Storage: 4°C, sealed, away from moisture and light
- In solvent storage: -80°C for 6 months; -20°C for 1 month (sealed, away from moisture and light)
- Reduces NO production and downregulates pro-inflammatory cytokines in human LPS-activated neutrophils
- Exhibits antiproliferative activity in GAMG (IC50 = 20.05 μM) and SKN-BE cells
- Impairs TNF-α liberation and inhibits IL-1α/β in mice in vivo
- For research use only
Medchemexpress LLC BNC375 | 1557240-80-8 | 99.6% | 50 MG
BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs, exhibiting an EC50 of 1.9 μM. It possesses good CNS-agent like properties and has clinical candidate potential. It significantly potentiates the acetylcholine signal without altering rapid receptor desensitization.
- Potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs.
- Exhibits good CNS-agent-like properties.
- Has clinical candidate potential.
- Significantly potentiates the acetylcholine signal.
- Achieves full reversal of scopolamine-induced impairment at 1.0 mg/kg in a mouse T-maze model.
- Minimum effective dose (MED) of 0.03 mg/kg.
- Plasma half-life (t1/2) of 1.2 hours.
Medchemexpress LLC Surfactin | 252023-70-4 | 98.96% | 50 MG
Surfactin is a potent cyclic lipopeptide biosurfactant consisting of four isomers (Surfactin A, B, C, and D). It mediates the flux of mono- and divalent cations, such as calcium, across lipid bilayer membranes. Surfactin acts as an antimicrobial adjuvant with antibacterial, antifungal, antimycoplasma, and hemolytic effects, and has antiviral activity against various enveloped viruses.
- Potent cyclic lipopeptide biosurfactant
- Consists of four isomers
- Mediates flux of mono- and divalent cations across lipid bilayer membranes
- Acts as an antimicrobial adjuvant
- Exhibits antibacterial, antifungal, and antimycoplasma effects
- Has antiviral activity against various enveloped viruses
Research Products International Corp Creatine Phosphate 100 G
Molecular Formula: C4H8N3O5PNa2. 4H2O
Molecular Weight:?327.14
CAS Number:?922-32-7
TARGETMOL CHEMICALS INC CREATINE 100MG
Also available in 5 mg 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Creatine (Methylguanidoacetic acid) is an amino acid that occurs in vertebrate tissues and in urine. In muscle tissue creatine generally occurs as phosphocreatine. Creatine is excreted as creatinine in the urine. Creatine functions as part of the cell's energy shuttle. The high energy phosphate group of ATP is transferred to creatine to form phosphocreatine in the following reaction Cr + ATP <-> PCr + ADP. This reaction is reversibly catalyzed by creatine kinase. In the human body creatine is synthesized mainly in the liver by the use of parts from three different amino acids arginine glycine and methionine. 95% of it is later stored in the skeletal muscles and the rest is stored in the brain heart and testes. purity: 99%